网络入侵检测方法研究

介绍了三种网络入侵检测系统的结构、原理和实现方法.     

FICSAM:一种适用于大型适应性系统的单例学习方法

对该方法的步骤、影响因素及特征进行了描述。同时,分析讨论了先聚后得法在计算机免疫系统GECISM中的应用及实验结果。     

ANN方法分析预测聚丙烯材料的力学性能

利用Ｂ－Ｐ人工神经网络（ＡＪＮＮ）对聚丙烯（ＰＰ）的力学性能进行了分析和预测。首先将ＰＰ材料接纯ＰＰ、共混和增韧及填充和增强ＰＰ等进行分类,并根据这些数据的特点建立Ｂ－Ｐ网络,然后用各类ＰＰ材料的组成和力学性能数据对网络进行学习训练,最后用“未知样品”的数据对网络进行验证。结果表明,所建立的网络能反映ＰＰ的力学性能特性,预测有一定的准确性,但不同类别的材料预测准确性不同。     

寡糖的结构,生物学功能及其应用

寡糖存在于许多生物大分子中,它所起的生物学功能已逐渐被人们认识,对它的研究受到人们的普遍关注。主要介绍寡糖的结构理论,生物学功能的研究进展及应用前景。     

2′,3′-Cyclic GMP-AMP Dinucleotides for STING-Mediated Immune Modulation: Principles,Immunotherapeutic Potential,and Synthesis

The cGAS-STING pathway discovered ten years ago is an important component of the innate immune system. Activation of cGAS-STING triggers downstream signalling, such as TBK1-IRF3, NF-κB and autophagy, which in turn leads to antipathogen responses, durable antitumour immunity or autoimmune diseases. 2′,3′-Cyclic GMP-AMP dinucleotides (2′,3′-cGAMP), the key second messengers produced by cGAS, play a pivotal role in cGAS-STING signalling by binding and activating STING. Thus, 2′,3′-cGAMP has immunotherapeutic potential, which in turn has stimulated research on the design and synthesis of 2′,3′-cGAMP analogues for clinical applications over the past ten years. This review presents the discovery, metabolism, and function of 2′,3′-cGAMP in the cGAS-STING innate immune signalling axis. The enzymatic and chemical syntheses of 2′,3′-cGAMP analogues as STING-targeting therapeutics are also summarized.